Adrenal Crisis

Adrenal crisis or insufficiency is a life threatening emergency due to the lack of glucocorticoid. Adrenal crisis can be primary due to destruction of the adrenal cortex (Addison’s), or secondary due to down regulation (chronic steroid use)


  • Brain: Fatigue, Confusion, Reduced GCS
  • CVS: Hypotension, Syncope, Arrhythmia (hyperkalaemia)
  • GIT: Abdo pain, Diarrhoea, Vomiting, Weight loss
  • Fever
  • Skin: Hyper-pigmentation (primary), Pale (secondary)


Treatment (of crisis)

  • Hydrocortisone 100mg IV (will then need need maintenance)
  • NaCl 0.9% 1000ml in 1st hour (may need 4-6l in the 1st day, so close monitoring required)
  • Treat electrolyte disturbance


  • Unwell with: fever, bed rest, antibiotics – Double the steroids (make sure they have enough)
  • Vomiting – will need IV

PDF:Adrenal Crisis

Searchs: hyperkalemia, addisons, addisonian

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