Octaplex – work fast its an EMERGENCY!

  • Activate EARLY in head injury patients on warfarin.
  • Order on EPR & Paper [see below]
    • Infuse over no more than 30 min
    • Recheck INR at 30 min after finished infusion


  • EMERGENCY reversal of Warfain
  • Factor II or X deficiency


  • Allergy
  • DIC
  • Previous HIT (heparin induced thrombocytopenia) • High risk Thrombosis
  • Recent MI
  • Decompensated Liver disease
  • Pregnancy
  • Sepsis


  • Request from Haematology On-Call [This can happen before CT]
  • Weight [Estimate if unknown]
  • INR/Clotting required

Prescribing Octaplex on EPR

  • Requests & Care Plans OR Quick Orders
  • Search: Blood Components
  • Coag Factors select YES 
  • Coag Factor product and units free text Octaplex & Dose
  • Complete ALL mandatory fields
  • To collect & give Octaplex the [Paper] Transfusion Care Pathway  must also be completed

UNSURE if your patient has received OCTAPLEX DON’T ASSUME. Check transfusion have dispensed it!


  • Typically 2000-3000units (Haematologist will give the dose)
  • Each 500units made up to 20ml (blue colour)
    • 1st 5min 1ml per min (Observing for allergy)
    • Then increase rate by 1ml per min (every 1-2 min) o Maximum rate 8ml per min

Full dose is typically given within 30min


  • Repeat Clotting at 20-30min post infusion
  • Inadequate responce discuss with Haematologist



Leave a Reply

Your email address will not be published. Required fields are marked *

This site uses Akismet to reduce spam. Learn how your comment data is processed.